Referenzen und Wichtige Informationen

5.1 Wissenschaftliche Referenzen

Die auf den vorherigen Seiten dargestellten Informationen basieren auf einer Vielzahl wissenschaftlicher Studien und Übersichtsarbeiten. Eine detaillierte Liste der verwendeten Quellen finden Sie am Ende dieses Dokuments. Diese Referenzen belegen die wissenschaftliche Grundlage der Aussagen und ermöglichen es interessierten Lesern, die Primärquellen zu konsultieren.

5.2 Wichtige Hinweise: Dosierung und Sicherheit

Obwohl Trans-Resveratrol, Piperin und Spermidin natürliche Substanzen sind, ist es wichtig, Informationen zur Dosierung und Sicherheit zu beachten:

Trans-Resveratrol:

• Dosierung: In vielen Humanstudien wurden Dosen zwischen 30 mg und 300 mg pro Tag verwendet, die positive Effekte zeigten. Resveratrol gilt im Allgemeinen als gut verträglich, auch in höheren Dosen bis zu 1 g pro Tag in vielen Studien. Kurzfristig wurden sogar bis zu 5 g pro Tag getestet.  
• Vorsicht bei hohen Dosen: Eine Pilotstudie an übergewichtigen älteren Erwachsenen (65+) deutete darauf hin, dass sehr hohe Dosen (1000 mg/Tag) bestimmte kardiovaskuläre Risikomarker erhöhen könnten, während 300 mg/Tag dies nicht taten. Dies unterstreicht, dass moderate Dosen vorzuziehen sein könnten.  
• Nebenwirkungen: Bei sehr hohen Dosen (über 1-2 g/Tag) können milde Nebenwirkungen wie Durchfall, Übelkeit oder Kopfschmerzen auftreten.  
• Wechselwirkungen: Resveratrol kann (insbesondere in hohen Dosen über 1 g/Tag) die Blutgerinnung beeinflussen und mit Blutverdünnern (wie Warfarin, Aspirin, Ibuprofen) interagieren. Auch Wechselwirkungen mit Blutdruckmedikamenten und anderen Medikamenten, die über die Leber verstoffwechselt werden, sind möglich.  
• Sonstige Vorsichtsmaßnahmen: Personen mit östrogenempfindlichen Erkrankungen sollten vor der Einnahme Rücksprache halten.  

Piperin:

• Dosierung: Die zur Verbesserung der Bioverfügbarkeit verwendeten Dosen sind typischerweise niedrig (5-20 mg pro Tag).  
• Sicherheit: In diesen geringen Mengen gilt Piperin als sicher.  
• Wechselwirkungen: Da Piperin den Stoffwechsel anderer Substanzen (über Leberenzyme und Transportproteine) beeinflussen kann, ist bei gleichzeitiger Einnahme von Medikamenten generell Vorsicht geboten und eine Rücksprache mit dem Arzt ratsam.  

Spermidin:

• Dosierung: Spermidin kommt natürlich in der Nahrung vor. Der Körper kann es aber auch selbst herstellen. In Supplementierungsstudien wurden meist Dosen von ca. 0.9 mg bis 3.3 mg pro Tag verwendet. Die EU-Obergrenze für Weizenkeimextrakte als neuartiges Lebensmittel liegt bei 6 mg pro Tag.  
• Sicherheit & Verträglichkeit: In den verwendeten Dosierungen wurde Spermidin in Studien gut vertragen.  
• Aufnahme: Eine neuere Studie stellte in Frage, ob höhere Dosen von supplementiertem Spermidin (15 mg) die Blut-/Speichelspiegel signifikant erhöhen, und vermutete eine Umwandlung in Spermin. Dies beeinflusst nicht zwangsläufig die in anderen Studien beobachteten potenziellen Vorteile bei niedrigeren Dosierungen, zeigt aber, dass die Pharmakokinetik komplex ist.  

Allgemeiner Haftungsausschluss:

Die hier bereitgestellten Informationen dienen ausschließlich Informationszwecken und ersetzen keine professionelle medizinische Beratung. Nahrungsergänzungsmittel sind nicht dazu bestimmt, Krankheiten zu diagnostizieren, zu behandeln, zu heilen oder zu verhindern.  

Konsultieren Sie immer Ihren Arzt oder Apotheker, bevor Sie mit der Einnahme neuer Nahrungsergänzungsmittel beginnen, insbesondere wenn Sie:

• bereits Medikamente einnehmen
• an chronischen Erkrankungen leiden
• schwanger sind oder stillen

Die Produkte sind nicht für schwangere oder stillende Frauen sowie Kinder bestimmt. Überschreiten Sie nicht die empfohlene Tagesdosis. Bewahren Sie die Produkte außerhalb der Reichweite von kleinen Kindern auf.  

5.3 Entdecken Sie unsere Produkte

Die auf diesen Seiten diskutierten wissenschaftlichen Erkenntnisse über Trans-Resveratrol, seine verbesserte Nutzung durch Piperin und seine synergistische Partnerschaft mit Spermidin bilden die Grundlage für unsere hochwertigen Produkte auf go-spermidin.eu.

• Entdecken Sie unser Trans-Resveratrol + Piperin, formuliert für eine optimierte Aufnahme und Nutzung dieses wertvollen Pflanzenstoffs.
• Erwägen Sie die Kombination mit unserem Spermidin-Produkt, um das synergistische Potenzial beider Naturstoffe zur Unterstützung Ihrer Zellgesundheit und Ihres Wohlbefindens zu nutzen.

Besuchen Sie unsere Produktseiten für detaillierte Informationen und um Ihre Bestellung aufzugeben. Investieren Sie in Ihre Zellgesundheit – für mehr Vitalität und Wohlbefinden in jedem Alter.

Referenzliste

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54. Biotikon. Resveratrol mit Piperin, verbesserte Bioverfügbarkeit.  
55. Amazon.de. HIVITAL Trans-Resveratrol + Nicotinamid.  
56. Sensilab. Sensilab Essentials Resveratrol 500mg.  
57. Ketoshop.ch. TRANS-RESVERATROL KAPSELN BRAINEFFECT.  
58. Health-Rise. Vitaworld Trans-Resveratrol 550 mg.  
59. Nguyen, C., et al. Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL). PLoS Med. 2024.  
60. Liu, T. T., et al. Molecular and Cellular Mechanisms of Spermidine in Age-Related Diseases. Oxid Med Cell Longev. 2021.  
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62. Hofer, S. J., et al. Spermidine is essential for fasting-mediated autophagy and longevity. Nat Cell Biol. 2024.  
63. Morselli, E., et al. Spermidine: a novel autophagy inducer and longevity elixir. Autophagy. 2010.  
64. Hofer, S. J., et al. Mechanisms of spermidine-induced autophagy and geroprotection. Nat Aging. 2022.  
65. Xu, T. T., et al. Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging (Albany NY). 2020.  
66. Sharma, S., et al. Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders. Neuropeptides. 2020.  
67. Sodji, Q. Spermidine to the rescue for an aging heart. Nat Med. 2016.  
68. Yan, J., et al. Spermidine-Activated Nitric Oxide Signaling Promotes Mitochondrial Biogenesis and Attenuates Cardiac Aging in Rats. Oxid Med Cell Longev. 2020.  
69. Lefèvre, C., et al. Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes. Biochem Soc Trans. 2018.  
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71. Senekowitsch, S., et al. High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study. Nutrients. 2023.  
72. Pekar, T., et al. Spermidine in dementia – Relation to age and memory performance. Wien Klin Wochenschr. 2021.  
73. Wirth, M., et al. The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex. 2018.  
74. Alzheimer Forschung Initiative e.V. Spermidin: Jungbrunnen für die Zellen?  
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78. Spermidin.health. Spermidin in Lebensmitteln: Die ultimative Liste.  
79. Spermidin Plus. Spermidin in Lebensmitteln: Tabelle & Tipps.  
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82. Online Fitness Academy. Spermidin: Wirkung, Nutzen & Lebensmittel.  
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Im Bericht verwendete Quellen

Referenzen

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Health Effects of Resveratrol: Results from Human Intervention Trials – PMC, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6317057/

Resveratrol: Health Benefits, Safety Information, Dosage, and More – WebMD, Zugriff am April 30, 2025, https://www.webmd.com/diet/health-benefits-resveratrol

Trans-Resveratrol – Alles zu Wirkung und Herkunft des Pflanzenstoffs – Braineffect, Zugriff am April 30, 2025, https://www.brain-effect.com/magazin/trans-resveratrol-wirkung-herkunft

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Resveratrol, Potential Therapeutic Interest in Joint Disorders: A …, Zugriff am April 30, 2025, https://www.mdpi.com/2072-6643/9/1/45

Piperin: Der Wirkstoff aus Pfeffer – Zentrum der Gesundheit, Zugriff am April 30, 2025, https://www.zentrum-der-gesundheit.de/ernaehrung/lebensmittel/inhaltsstoffe/piperin

Piperin – Wirkung und Eigenschaften. Wann zeigen sich die ersten Wirkungen? – Natu.Care, Zugriff am April 30, 2025, https://natu.care/de/pflanzen/piperin

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Trans-Resveratrol Supplement – Organic Capsules – Vegan Supplements for Women and Men, Natural Antioxidant, Polyphenols Supplement, Anti Aging – 60 Capsules, 600mg, 30 Day Supply – Amazon.com, Zugriff am April 30, 2025, https://www.amazon.com/Trans-Resveratrol-Supplement-Cardiovascular-Anti-inflammatory/dp/B086VT5GXW

Natural Autophagy Activators to Fight Age-Related Diseases – PMC – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC11476028/

Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases – MDPI, Zugriff am April 30, 2025, https://www.mdpi.com/2076-3921/14/1/70

SIRT1 and Autophagy: Implications in Endocrine Disorders – Frontiers, Zugriff am April 30, 2025, https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.930919/full

Natural Autophagy Activators to Fight Age-Related Diseases – MDPI, Zugriff am April 30, 2025, https://www.mdpi.com/2073-4409/13/19/1611

Alma Mater Studiorum Università di Bologna Archivio istituzionale, Zugriff am April 30, 2025, https://cris.unibo.it/bitstream/11585/480768/4/2015012975_AM.pdf

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome – PMC – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC3044119/

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/21339330/

Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC2815753/

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases – PMC, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6251315/

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease – PMC – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC3699815/

Health benefits of resveratrol: Evidence from clinical studies – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/30741437/

Protective Effect of Resveratrol on Knee Osteoarthritis and its …, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC9357872/

Resveratrol: A Double-Edged Sword in Health Benefits – PMC – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6164842/

www.zentrum-der-gesundheit.de, Zugriff am April 30, 2025, https://www.zentrum-der-gesundheit.de/ernaehrung/lebensmittel/inhaltsstoffe/resveratrol#:~:text=Lebensmittel%20mit%20Resveratrol,%2C%20Soja%2C%20Schokolade%20und%20Erdn%C3%BCssen.

Was ist Trans-Resveratrol? – Vorteile | Purovitalis, Zugriff am April 30, 2025, https://purovitalis.com/de/was-ist-trans-resveratrol/

5 Resveratrol-Lebensmittel, die du mehr essen solltest – Purovitalis, Zugriff am April 30, 2025, https://purovitalis.com/de/5-resveratrol-lebensmittel/

Enhancing the bioavailability of resveratrol by combining it with piperine – PMC, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC3295233/

REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial – Frontiers, Zugriff am April 30, 2025, https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1359330/full

Higher Dose of Resveratrol Elevated Cardiovascular Disease Risk …, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC8168448/

Resveratrol PLUS – 1350mg Trans-Resveratrol pro Tag – plantomol, Zugriff am April 30, 2025, https://plantomol.de/products/resveratrol-plus-kapseln-aus-staudenknoterich

Trans-Resveratrol – Braineffect – Ketoshop.ch, Zugriff am April 30, 2025, https://ketoshop.ch/nahrungsmittel/supplements/trans-resveratrol-braineffect/

Vitaworld Trans-Resveratrol 550 mg | 60 Kapseln | vegan – Health Rise, Zugriff am April 30, 2025, https://www.health-rise.de/vitaworld-trans-resveratrol-550-mg-60-kps

Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/32900519/

www.j-stroke.org, Zugriff am April 30, 2025, https://www.j-stroke.org/upload/pdf/jos-2023-02733.pdf

Zubereitungen aus Trauben – – OPC, Resveratrol und andere Inhaltsstoffe, Zugriff am April 30, 2025, https://www.uniklinik-freiburg.de/fileadmin/mediapool/08_institute/rechtsmedizin/pdf/Zubereitungen_aus_Trauben_-__OPC__Resveratrol_und_andere_Inhaltsstoffe.pdf

Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation | British Journal of Nutrition – Cambridge University Press, Zugriff am April 30, 2025, https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-resveratrol-alone-or-in-combination-with-piperine-on-cerebral-blood-flow-parameters-and-cognitive-performance-in-human-subjects-a-randomised-doubleblind-placebocontrolled-crossover-investigation/772AD010D210C0394A4EBE9C90C8B7C6

Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/24804871/

Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial – MDPI, Zugriff am April 30, 2025, https://www.mdpi.com/2072-6643/9/1/27

A Randomized, Double-Blind, Dose-Ranging, Pilot Trial of Piperine with Resveratrol on the Effects on Serum Levels of Resveratrol, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC7910313/

The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/26344014/

Piperine, Black Pepper (Piper nigrum) – Restorative Medicine, Zugriff am April 30, 2025, https://restorativemedicine.org/library/monographs/piperine-black-pepper/

Cardioprotective Potential of Resveratrol Alone and in Combination with Piperine on Isoproterenol-induced Myocardial Infarction in Rat – International Journal of Pharmaceutical Investigation, Zugriff am April 30, 2025, https://jpionline.org/article/32592/

Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/35431994/

Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC9009313/

Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults – A pilot study – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/31891746/

The search for anti-aging interventions: From elixirs to fasting regimens – PMC, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC4254402/

Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC10815776/

Evolution of pain at 3 months by oral resveratrol in knee …, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC5640106/

Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL) – PLOS, Zugriff am April 30, 2025, https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004440&type=printable

(PDF) Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL) – ResearchGate, Zugriff am April 30, 2025, https://www.researchgate.net/publication/383086490_Oral_resveratrol_in_adults_with_knee_osteoarthritis_A_randomized_placebo-controlled_trial_ARTHROL

Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL) | PLOS Medicine, Zugriff am April 30, 2025, https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004440

Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL) – PMC, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC11321588/

Evolution of pain at 3 months by oral resveratrol in knee osteoarthritis (ARTHROL): protocol for a multicentre randomised double-blind placebo-controlled trial – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/28965100/

Mitochondria and sensory processing in inflammatory and neuropathic pain – Frontiers, Zugriff am April 30, 2025, https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2022.1013577/full

A randomized, double-blind, dose-ranging, pilot trial of piperine with resveratrol on the effects on serum levels of resveratrol | Request PDF – ResearchGate, Zugriff am April 30, 2025, https://www.researchgate.net/publication/343985403_A_randomized_double-blind_dose-ranging_pilot_trial_of_piperine_with_resveratrol_on_the_effects_on_serum_levels_of_resveratrol

Structure, physicochemical properties and pharmacokinetics of resveratrol and piperine cocrystals | Request PDF – ResearchGate, Zugriff am April 30, 2025, https://www.researchgate.net/publication/319704655_Structure_physicochemical_properties_and_pharmacokinetics_of_resveratrol_and_piperine_cocrystals

Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution? – MDPI, Zugriff am April 30, 2025, https://www.mdpi.com/1420-3049/19/11/17154

Enhancing Bioavailability of Nutraceutically Used Resveratrol and Other Stilbenoids – MDPI, Zugriff am April 30, 2025, https://www.mdpi.com/2072-6643/13/9/3095

Enhancing the bioavailability of resveratrol by combining it with piperine – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/21714124/

Piperine potentiates the antidepressant-like effect of trans-resveratrol: involvement of monoaminergic system – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/23943324/

Piperine potentiates the effects of trans-resveratrol on stress-induced depressive-like behavior: involvement of monoaminergic system and cAMP-dependent pathway – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/26946512/

SCHWARZER PFEFFER EXTRAKT BioPerine® (50:1) 20 mg – HSN, Zugriff am April 30, 2025, https://www.hsnstore.de/marken/essential-series/schwarzer-pfeffer-extrakt-bioperine-50-1-20-mg

Piperin Wirkung, Vorkommen, Dosierung und Nebenwirkungen – Quantum Leap Fitness, Zugriff am April 30, 2025, https://quantumleapfitness.de/blogs/fitness-magazin/piperin-wirkung

Resveratrol mit Piperin, verbesserte Bioverfügbarkeit – Biotikon DE, Zugriff am April 30, 2025, https://www.biotikon.de/blog/resveratrol-mit-piperin-verbesserte-bioverfuegbarkeit

Enhancing the bioavailability of resveratrol by combining it with piperine – WCM-Q SEARCH, Zugriff am April 30, 2025, https://primo.qatar-weill.cornell.edu/discovery/fulldisplay?docid=cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3295233&context=PC&vid=974WCMCIQ_INST:VU1&lang=en&adaptor=Primo%20Central

Trans-Resveratrol 500 mg. 90 vegane Kapseln für 3 Monate. Mit Nicotinamid und Piperin. Natürlicher Extrakt aus Fallopia Japonica 98% reines natürliches Resveratrol zur Verlangsamung der Zellalterung. – Amazon.de, Zugriff am April 30, 2025, https://www.amazon.de/Trans-Resveratrol-Nicotinamid-Nat%C3%BCrlicher-nat%C3%BCrlichem-Zellalterung/dp/B0BYJVJGPH

Essentials Resveratrol 500 mg hochdosiert – vegan, 180 Kapseln (3 Packungen), Zugriff am April 30, 2025, https://www.sensilab.de/sensilab-essentials-resveratrol-500mg-resveratrol-kapseln-3x

New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC8612618/

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6287690/

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/30306826/

High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC10143675/

Spermidin zur Vorbeugung von Demenz? | Alzheimer Forschung Initiative e.V. (AFI), Zugriff am April 30, 2025, https://www.alzheimer-forschung.de/forschung/aktuell/spermidin/

Spermidin: Wirkung und Nebenwirkung – netDoktor.de, Zugriff am April 30, 2025, https://www.netdoktor.de/medikamente/spermidin/

Jungbleiben mit Spermidin? – Klartext Nahrungsergänzung, Zugriff am April 30, 2025, https://www.klartext-nahrungsergaenzung.de/wissen/lebensmittel/nahrungsergaenzungsmittel/jungbleiben-mit-spermidin-51804

Welche Lebensmittel enthalten Spermidin?, Zugriff am April 30, 2025, https://www.spermidin-plus.at/magazin/spermidin-in-lebensmitteln

Jungbleiben mit Spermidin? | EAT SMARTER, Zugriff am April 30, 2025, https://eatsmarter.de/blogs/live-smarter/spermidin

Spermidin: Wirkung, Vorteile und Nebenwirkungen – Online Fitness Academy (OFA), Zugriff am April 30, 2025, https://www.online-fitness-academy.de/magazin/spermidin.html

Anti-Aging: Spermidin mindert Haarausfall und schützt das Herz – Medizinische Hochschule Hannover, Zugriff am April 30, 2025, https://www.mhh.de/presse-news/anti-aging-spermidin-mindert-haarausfall-und-schuetzt-das-herz

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial – PMC, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6492385/

Spermidin: Wirklich ein Jungbrunnen? | MDR.DE, Zugriff am April 30, 2025, https://www.mdr.de/wissen/medizin-gesundheit/spermidin-altern-anti-aging-wirkung-studie-ergebnis100.html

The Effect of Spermidine Supplementation on Cognitive Function in Adults: A Mini-Review – Principles and Practice of Clinical Research, Zugriff am April 30, 2025, https://journal.ppcr.org/index.php/ppcrjournal/article/download/284/273

Spermidine: a novel autophagy inducer and longevity elixir – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/20110777/

Mechanisms of spermidine-induced autophagy and geroprotection – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/37118547/

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/32268299/

Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/32873420/

Spermidin: Ein Schlüssel zur Zellreinigung und kognitiven Gesundheit im Alter, Zugriff am April 30, 2025, https://gesundheitsportal-badessen.de/spermidin-ein-schluessel-zur-zellreinigung-und-kognitiven-gesundheit-im-alter/

Mit Fasten gesund alt werden: Spermidin als Schlüssel zum Erfolg – Universität Graz, Zugriff am April 30, 2025, https://www.uni-graz.at/de/neuigkeiten/mit-fasten-gesund-alt-werden-spermidin-als-schluessel-zum-erfolg/

Hallmarks of Aging: An Autophagic Perspective – PMC – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6333684/

Spermidine to the rescue for an aging heart – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/27923032/

Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6977682/

Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/30578348/

The Anti-Aging Supplements Dr. David Sinclair Takes Besides NMN, Zugriff am April 30, 2025, https://www.nmn.com/news/the-anti-aging-supplements-dr-david-sinclair-takes-daily-nmn-included

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/35616942/

The positive effect of spermidine in older adults suffering from dementia: First results of a 3-month trial – PMC, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC8116233/

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC9136623/

Spermidin verbessert Denkvermögen und Gedächtnisleistung – myPoint – Medizinische Universität Innsbruck, Zugriff am April 30, 2025, https://www.i-med.ac.at/mypoint/news/752689.html

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline – Aging-US, Zugriff am April 30, 2025, https://www.aging-us.com/article/101354/text

(PDF) Spermidine in dementia – Relation to age and memory performance – ResearchGate, Zugriff am April 30, 2025, https://www.researchgate.net/publication/337921456_Spermidine_in_dementia_-_Relation_to_age_and_memory_performance

Non-Linear Association of Dietary Polyamines with the Risk of Incident Dementia: Results from Population-Based Cohort of the UK Biobank – MDPI, Zugriff am April 30, 2025, https://www.mdpi.com/2072-6643/16/16/2774

The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/33211152/

The positive effect of spermidine in older adults suffering from dementia after 1 year, Zugriff am April 30, 2025, https://www.researchgate.net/publication/371377091_The_positive_effect_of_spermidine_in_older_adults_suffering_from_dementia_after_1_year

Non-linear association between serum spermidine and mild cognitive impairment: Results from a cross-sectional and longitudinal study – Frontiers, Zugriff am April 30, 2025, https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.924984/full

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline A Randomized – Publication Server of the University of Greifswald, Zugriff am April 30, 2025, https://epub.ub.uni-greifswald.de/files/10444/schwarz_2022_oi_220408_1652900435.83926.pdf

Exploitation of Autophagy Inducers in the Management of Dementia: A Systematic Review, Zugriff am April 30, 2025, https://www.mdpi.com/1422-0067/25/2/1264

Neue Studie: Spermidinreiche Ernährung hält den Menschen länger jung – myPoint – Medizinische Universität Innsbruck, Zugriff am April 30, 2025, https://www.i-med.ac.at/mypoint/news/719834.html

Spermidin: Anti-Aging-Effekt unklar – Medizin transparent, Zugriff am April 30, 2025, https://medizin-transparent.at/spermidin/

SIRT1 activity is required for resveratrol-induced autophagy but not… – ResearchGate, Zugriff am April 30, 2025, https://www.researchgate.net/figure/SIRT1-activity-is-required-for-resveratrol-induced-autophagy-but-not-for_fig1_49853409

Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6349451/

Synergy of NMN, Resveratrol and Spemidine. How They All Work Together for Anti-aging?, Zugriff am April 30, 2025, https://rescence.com/synergy-of-nmn-resveratrol-spermidine/

PURELY beneficial RESVERATROL1450-90day Supply, 1450mg per Serving of Potent Antioxidants & Trans-Resveratrol, Promotes Anti-Aging, Cardiovascular Support, Maximum Benefits (1bottle) – Amazon.com, Zugriff am April 30, 2025, https://www.amazon.com/RESVERATROL1450-90day-Antioxidants-Trans-Resveratrol-Anti-Aging-Cardiovascular/dp/B01N3746GJ

Resveratrol – Memorial Sloan Kettering Cancer Center, Zugriff am April 30, 2025, https://www.mskcc.org/cancer-care/integrative-medicine/herbs/resveratrol

Transport, stability, and biological activity of resveratrol – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/21261641/

Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/38433010/

Evolution of pain at 3 months by oral resveratrol in knee osteoarthritis (ARTHROL) – BMJ Open, Zugriff am April 30, 2025, https://bmjopen.bmj.com/content/bmjopen/7/9/e017652.full.pdf

Evolution of pain at 3 months by oral resveratrol in knee osteoarthritis (ARTHROL): Protocol for a multicentre randomised double-blind placebo-controlled trial – ResearchGate, Zugriff am April 30, 2025, https://www.researchgate.net/publication/318865972_Evolution_of_pain_at_3_months_by_oral_resveratrol_in_knee_osteoarthritis_ARTHROL_Protocol_for_a_multicentre_randomised_double-blind_placebo-controlled_trial

The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/39872318/

The effect of resveratrol supplementation on biomarkers of liver health: A systematic review and meta-analysis of randomized controlled trials – PubMed, Zugriff am April 30, 2025, https://pubmed.ncbi.nlm.nih.gov/36642444/

A systematic review and meta-analysis of the impact of resveratrol on oral cancer: potential therapeutic implications, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC10993553/

Resveratrol supplementation, where are we now and where should we go? – PMC, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC5835393/

Spermidine is essential for fasting-mediated autophagy and longevity – PMC – PubMed Central, Zugriff am April 30, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC11392816/

Spermidinreiche Lebensmittel: Die vollständige Liste | Purovitalis, Zugriff am April 30, 2025, https://purovitalis.com/de/lebensmittel-mit-spermidin-vollstandige-liste/

Spermidin in Lebensmitteln, Zugriff am April 30, 2025, https://spermidin.health/spermidin/spermidin-in-lebensmitteln/

Spermidin Lebensmittel: Deine Quellen für eine ausgewogene Ernährung – plantomol, Zugriff am April 30, 2025, https://plantomol.de/blogs/ernaehrung/spermidin-lebensmittel